Blar i forfatter "Khan, Mahmud Tareq Hassan"

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    • The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor 

      Kostenko, Sergiy Viktorovich; Khan, Mahmud Tareq Hassan; Sylte, Ingebrigt; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The mitogen-activated protein kinase-activated protein kinase MK5 is ubiquitously expressed in vertebrates and is implicated in cell proliferation, cytoskeletal remodeling, and anxiety behavior. This makes MK5 an attractive drug target. We tested several diterpenoid alkaloids for their ability to suppress MK5 kinase activity. We identified noroxoaconitine as an ATP competitor that inhibited the ...

    • Induction of apoptosis of human primary osteoclasts treated with extracts from the medicinal plant Emblica officinalis 

      Khan, Mahmud Tareq Hassan; Penolazzi, Letizia; Lampronti, Ilaria; Borgatti, Monica; Khan, Mahmud Tareq Hassan (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-10-30)
      Background: Osteoclasts (OCs) are involved in rheumatoid arthritis and in several pathologies associated with bone loss. Recent results support the concept that some medicinal plants and derived natural products are of great interest for developing therapeutic strategies against bone disorders, including rheumatoid arthritis and osteoporosis. In this study we determined whether extracts of Emblica ...